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Clinical studies have also indicated that metformin alone can increase GLP-1 levels, via a mechanism distinct from DPP-4 inhibition, and that combination therapy has a complementary effect on GLP-1 concentrations [27]

Men in the study experienced greater anabolic benefits, including improvements in insulin sensitivity and quality of life markers

A direct relationship has also been established between the regulation of food intake and energy homeostasis and hypothalamic metabolic sensor activities