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Most patients are still at low doses (2.5 mg tirzepatide, 0.25 mg semaglutide) and haven't yet experienced significant fluid shifts
Fortinos clinics in Philadelphia and South Jersey
Moreover, a counterintuitive reduction in N-terminal pro B-type natriuretic peptide concentrations on top of weight reduction has been shown in both STEP HFpEF trials, indicating potential direct cardiac effects of the therapies
Additionally, the coronary endothelium has been shown to influence left ventricular diastolic function through paracrine effects in both healthy individuals and post-transplant patients [19]
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