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Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist
Quercetin also helps other natural compounds, like resveratrol, boost their effectiveness
In summary for cardiac surgery: robust evidence links mtDAMPs and immune activation to postoperative complications (34)
Consequently, ROS levels likely increase during prolonged wakefulness, suggesting that sleep may function in ROS clearance or that sleep deprivation exacerbates ROS accumulation
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