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The determination of an appropriate maintenance dose should consider: Degree of weight loss achieved : Generally, at least 5% body weight reduction is considered clinically meaningful Tolerability profile : Persistent gastrointestinal symptoms may necessitate maintaining at a lower dose Comorbidity improvement : Changes in blood pressure, lipids, glycemic parameters, and other obesity-related conditions Patient preferences and quality of life : Balancing efficacy with side effect burden According to clinical guidelines, patients should be reassessed after approximately 3 months on a maintenance dose
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