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The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms
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1,2 However, the overproduction of ROS can induce cytotoxicity and lead to DNA damage and cell apoptosis
In addition, the application of phosphate fertilizers, excess industrial chemical waste, and sewage sludge are actively involved in increasing HMs-toxicity to plants, soils, and environments [3, 4]
P., Saxena R., Gebhard D
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