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Why It Works: Modulates nitric oxide bioavailability at the eNOS level, helping stabilize the balance between vasodilation and vasoconstriction in injured tissue Upregulates VEGFR2 expression and drives VEGF-mediated angiogenesis, supporting new blood vessel formation at injury sites Protects cell-matrix adhesion through FAK-paxillin signaling and appears to dampen local inflammatory cascades via NF-B modulation Best For: Tendon, ligament, and soft-tissue injury recovery, along with gut-lining and gastrointestinal repair research Typical Protocol: Preclinical/research protocols commonly reference 200-500 mcg per day via subcutaneous injection, split into one or two daily doses (with 250 mcg once or twice daily being a frequently cited starting range)
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Most events were transient, and mild or moderate in severity and resolved without permanent treatment discontinuation
Yao et al., 2023
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