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Taking more than recommended increases the risk of side effects

Body weight-based dosing around 4-6mcg per kilogram provides individualized starting points

Some patients find that taking their injection in the evening and sleeping through the peak nausea window (hours 24) makes the experience much more tolerable than daytime dosing

Expected metabolic improvements Weight loss from semaglutide typically produces favorable changes in fasting glucose (decreases), HbA1c (decreases), triglycerides (decreases), LDL cholesterol (modest decrease), HDL cholesterol (modest increase), blood pressure (decreases with weight loss), and inflammatory markers like C-reactive protein (decreases)