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Any safety discussion should therefore include downstream GH/IGF-1 effects as relevant endpoints

The irreversible effect of aspirin on platelet COX-1 lasts for the duration of the life of the platelet (~10 days), whereas any subsequent effect of aspirin on COX-2 expressed by nucleated cells, including vascular endothelial cells, can be modulated by their ability to generate COX enzyme de novo by continued translation and transcription of COX genes from cellular DNA (Evangelista et al, 2006