The compound activates the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the glucagon receptor simultaneously [1]
Potentially powerful effects with a more targeted mechanism than traditional performance-enhancing drugs
This mechanism bypasses the cardiovascular system, making it suitable for individuals who cannot use traditional treatments
Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]