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The predominantly hepatic metabolism of orforglipron does, however, raise the question of whether dose adjustment is needed in hepatic impairment, an issue that was addressed in dedicated hepatic impairment studies during the clinical development program

Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.)

Orlistat blocks fat absorption but causes unpleasant gastrointestinal effects when fat is consumed

For GLP-1 users specifically, the mindset piece matters in a few practical ways