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CrossRef Indole-3-carbaldehyde mitigates fibrosis progression in MASH with T2DM via the SIRT1/TGF-/SMAD signaling pathway Lu Li, Zeyu Wang, Yinglan Ji, Raorao Wang, Xiangjuan Qi, Yana Zhu, Yaping Wang, Xiaoyang Zhang, Man Li, Yong Jiang Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease .2026

Clinical trials have shown this dose produces significant weight loss over 56 weeks, with many participants achieving 510 % of baseline body weight reduction