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Microglial NF-B activation under GSH-depleted conditions creates a pro-inflammatory loop where increased ROS promotes NF-B activation, which upregulates inflammatory cytokines and further stimulates oxidative stress (Liu et al., 2017

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The primary concerns with nasal peptides involve nasal irritation if formulations arent pH-optimized, potential mucosal damage from preservatives, and variable absorption due to nasal congestion