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These differences are not unexpected given that SUSTAIN 6 and PIONEER 6 included subjects at high risk of CVD, and PIONEER 5 included subjects with renal impairment
PubMed Jiang H, Shi J, Li Y
It was found that even in aged mice, an improvement in memory formation was observed, and LTP in area CA1 was found to be strong and enduring in drug-treated AD mice but lacking in saline-treated AD mice
Phenformin In the late 1950s, Phenformin was introduced in the United States for the treatment of non-insulin-dependent (NIDDM) and was 50 times more powerful than metformin
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