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For most patients, with insurance, the out-of-pocket expense could be as low as $0 plus your copay for tirzepatide, making it an attractive option for weight loss injections with insurance coverage

However, Ozempic and Wegovy have gone through the FDA approval process, whereas compounded semaglutide is not FDA-approved and does not undergo safety, effectiveness, or manufacturing review by FDA

This qualitative difference suggests the glucagon component contributes something beyond simple appetite suppression, potentially shifting fundamental metabolic set points

You do not necessarily have to choose one over the other, as they support the body in complementary ways, but identifying your primary "friction points" can help you prioritize