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Clinical trials show superior gains in blood pressure, lipid profiles (reduced triglycerides, increased HDL cholesterol), swelling markers (reduced CRP, IL-6), liver enzymes (suggesting improved hepatic steatosis), and glycemic control compared to semaglutide alone

As the committee passed the drugs, Shabbir Imber Safdar was quoted in NBC News, saying, Compounding shouldnt be used as an end run around the safety assurances of the FDA approval process. Time Magazine also cited our concerns about the standards at 503A compounding pharmacies and the potential for people to think that these peptides have robust clinical evidence behind them as a result of being added to the list

Figure 4: Reduction in body weight from baseline level in treatment groups administered treatment with cagrilintide, semaglutide, or a combined treatment of both peptides