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Highest dose, obesity trial obesity-plus-diabetes trial (treatment-policy estimand): Semaglutide: 14.9% (STEP 1) 9.6% (STEP 2), a 5.3 point gap Tirzepatide: 20.9% (SURMOUNT-1) 14.7% (SURMOUNT-2), a 6.2 point gap Retatrutide: 25.0% (TRIUMPH-1) 20.8% (TRIUMPH-2 only efficacy-estimand currently reported so true gap is larger) It's still unclear the reason why we observe less weight loss in those with T2D
Before using compounded semaglutide and vitamin B12, tell your healthcare provider about All of your medical conditions
Managing reactions during dose changes and medication switches Dose escalation and medication transitions are the two highest-risk periods for injection site reactions outside of initial treatment
Hydroxyureas efficacy varies among patients, and gene therapies, though effective, are limited by issues of accessibility and affordability
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