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During follow-up, 12 patients in the oral semaglutide (10.4%) and 11 patients in the subcutaneous semaglutide (6.2%%) group discontinued treatment due to side effects, without significant differences between the two formulations ( p = 0.27) (Supplementry Figure S2o)
Common side effects include nausea, vomiting, and gastrointestinal symptoms, particularly during dose escalation
Benefits of a Morning Dose Aligns with routine blood glucose checks and breakfast planning
The dual activation not only reduces appetite but also slows digestion, enhances insulin sensitivity, and boosts energy expenditure
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