At present, drug resistance continues to be a significant contributing factor to the suboptimal patient prognosis
At presentation the patient was in a hyperosmolar (serum osmolarity 337mOsm) hyperglycaemic (plasma glucose 59 mmol/L) state complicated by anuric renal failure with a lactic acidosis
Although there is an ongoing controversy as to whether patients with NF1-associated, sporadic or radiation-induced MPNSTs have a worse prognosis 4,5,6,7,9 , there is general agreement that MPNSTs have a poor outcome irrespective of the clinical setting, with multiple medical centers reporting that patients with these tumors have five year disease-free survival rates of between 34 and 60% 6,8,10,11,12,13,14,15
His review highlights how the supplement fits into a demanding schedule without complicated rules