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One challenge to elucidating a mechanistic role for GLP-1Rs stems from their complex expression across multiple brain regions (1012), including the lateral septal nucleus (LSc), substantia nigra, ventral tegmental area (VTA), amygdala, nucleus accumbens (ACB), hippocampus, several regions of the hypothalamus (paraventricular nucleus of the hypothalamus [PVH], arcuate nucleus [ARH]), and hindbrain

The goal is to increase the dose gradually until the highest tolerable dose (a dose that reaches the desired effect without unacceptable side effects) is reached