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In between-drug comparisons, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 4.60 kg [95% CI 7.94, 1.26]), 1.0 mg (MD = 3.53 kg [95% CI 4.80, 2.25]) and 0.5 mg (MD = 2.75 kg [95% CI 4.23, 1.28]), respectively (ESM Table 11)

Albiglutide was less effective in activating the GLP-1R compared to exendin-4 in an in vitro study of a BHK cell line expressing the rat GLP-1R (92)

This weight loss medication regulates hormones in the brain, digestive system and adipose fat tissue to suppress appetite and cravings and promote a sense of fullness