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tirzepatide method of action Pharmacogenomics Tirzepatide: Genomic Insights into Dual GIP/GLP-1 Agonist Response in Type 2 Diabetes and Atherosclerosis Tirzepatide (Mounjaro/Zepbound): Research Guide |

Name: tirzepatide method of action Pharmacogenomics Tirzepatide: Genomic Insights into Dual GIP/GLP-1 Agonist Response in Type 2 Diabetes and Atherosclerosis Tirzepatide (Mounjaro/Zepbound): Research Guide |
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L.ModjadjiP.GhaffaryS

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Together with our present findings that GLP-1Rs are expressed primarily on VTA GABA neurons and that GLP-1R agonism increases c-Fos expression in VTA neurons, we hypothesized that systemic administration of a GLP-1R agonist would increase the activity of VTA GABA neurons and decrease cocaine seeking