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62 HeitmannB
While its efficacy and safety profile are comparable to oral Wegovy , it falls significantly short of Eli Lillys subcutaneous tirzepatide the gold standard of GLP-1 analogs to date (technically a dual agonist mimicking both GLP-1 and GIP)
Given that GLP-1-RAs alter gut motility and secretion, and that the gut microbiota can influence host eating behavior, including food preferences, it is plausible that these drugs indirectly influence taste perception by modulating microbial composition and the subsequent production of metabolites that can signal to the brain, potentially via vagal afferents or systemic circulation
The US remains the largest market for these medications
