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Further, fibrotic ECM is known to contribute to the increased stiffness of fibrotic tissues, and this stiffness is essential for sustained TGF responses as stiff ECM induces mechanical strain and can help position latent TGF near MMPs, facilitating the liberation of active TGF (31, 249)

The authors also acknowledge financial support from UGC-CAS doctoral fellowship (to P.P.), DST-INSPIRE fellowship (to O.M.) and CSIR-Junior research fellowship (to A.B.)

ABCA1 knockout mice had an impaired glucose tolerance but normal insulin sensitivity, suggesting that these mice suffered from islet -cell dysfunction

Intramuscular is possible but unnecessary SC delivers equivalent GH pulses with less injection pain