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Most research supports 1000-2000mg for fat loss and exercise performance, 1000mg for general energy support, and 2000-3000mg for heart health under medical supervision

The semaglutide cohort ( n = 1470) compared with the naltrexone/topiramate cohort ( n = 1430) was older, included more women, had a higher prevalence of severe obesity and obesity-associated comorbidities including T2DM and lower prevalence of adverse socioeconomic determinants of health, problems with lifestyle, and substance use disorders

Another drug, ES2, targets FOXO4 conserved region 3 (CR3) but has a significantly lower selectivity than FOXO4-DRI 25

Published in JAMA Network Open in 2024, the research dives into whether bariatric surgery or GLP-1 receptor agonist drugs offer a better shot at extending life for those battling both conditions