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While real-world data on the level of adherence to dual GLP1-RA/GIP agonists are not available to date, some considerations can be drawn from available clinical trials and experiences with other pharmacological classes
Notably, the same meta-analysis highlighted that liraglutide, particularly when compared to higher doses of semaglutide or tirzepatide, promoted weight loss without a clinically meaningful reduction in lean mass [77]
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