surmount-1 trial tirzepatide weight loss nondiabetic

surmount-1 trial tirzepatide weight loss nondiabetic once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 surmount-1 trial tirzepatide non-diabetic obesity

Name: surmount-1 trial tirzepatide weight loss nondiabetic once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 surmount-1 trial tirzepatide non-diabetic obesity
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In dermatology, clinical trials show a 55.8% reduction in wrinkle volume at 12 weeks (71 women, Pickart et al., BioMed Res Int 2015It also increases the size of hair follicles by 30 to 50% in preclinical models

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However, the GI side effects during the transition (particularly vomiting and diarrhea) can cause dehydration, which disproportionately affects people with compromised kidney function