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This property makes it valuable for joint health
Patients pairing GLP-1 therapy with HRT may experience: Greater total weight and fat loss compared to GLP-1 therapy alone Improved body composition and muscle tone Enhanced energy and daily performance More consistent, lasting results Clinical insights suggest that addressing hormonal imbalances alongside GLP-1 therapy may lead to up to 30% greater weight loss in appropriate candidates
Furthermore, SNS might increase energy expenditure by acting either on brown adipose tissue (BAT) thermogenesis or on the cardiovascular system: this neuronal pathway is modulated by leptin (Pandit et al., 2017) The role of SNS in lipolysis It is well known that lipolysis in the WAT is regulated by SNS and insulin, the principal initiator of lipolysis and a potent inhibitor of lipolysis respectively (Goodridge and Ball, 1965
Pediatr Hematol Oncol 23 , 381385
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