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In terms of topicals, hydroquinone has long been the gold standard for lightening melasma, says Sandra Lee, MD, a board-certified dermatologist and founder of SLMD Skincare

In adults with obesity, Tirzepatide produced substantial and sustained reductions in body weight, with nearly two-thirds of participants losing at least 20% of their baseline weight (Jastreboff, New England Journal of Medicine )

No GLP-1 patch is FDA approved: most are sold as wellness or supplement products that are never reviewed for dose or effectiveness before they reach the shelf