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[Drugs.com] Nagasawa, Herbert T

The chosen conditions cover two common stress factors, reduced and maximal carbon catabolite repression, and two nitrogen sources (urea versus ammonium sulfate)

Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease

We recommend a loading dose of 6 sessions spaced out over 2-3 weeks, followed by top up injections every 2-3 months