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Key points: Gastrointestinal side effects became more common as the dose rose in STEP UP, from 42.8% on placebo to 61.2% on 2.4 mg and 70.8% on 7.2 mg Altered skin sensations, such as tingling, were also more common on 7.2 mg (22.9%) than on 2.4 mg (6.0%) Nausea, diarrhoea, vomiting, and constipation are the most common side effects Side effects are usually worst just after a dose increase and often settle within a few weeks Its worth considering whether increasing the dose is worth the risk of increased side effects
Glutathione Dysregulation and the Etiology and Progression of Human Diseases. Biological Chemistry , vol
Acute kidney injury : Particularly in patients experiencing severe gastrointestinal side effects leading to dehydration
We computed the relative importance of each variable predicting the outcome using F scores in XGBoost, calculated as the sum of Gini improvement among the corresponding splits within a tree, averaged over all trees
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