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Unlike prior studies emphasizing single-organ effects, our analysis reveals that ferroptosis drives a self-reinforcing cycle: Hyperglycemia in DM triggers systemic iron overload, and the accumulation of iron in peripheral organs, combined with oxidative stress imbalance, causes organ damage (including pancreatic -cells), further exacerbating the progression of DM and forming a pathological feedback loop

Drug-induced malabsorption: Long-term medications like metformin or proton-pump inhibitors can reduce B12 absorption

A B12 IV infusion is an intravenous treatment that delivers vitamin B12 alongside hydrating fluids and complementary nutrients directly into the bloodstream