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Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant
These changes can be reversible or persistent, and they play a central role in how diseases develop or are prevented across the lifespan
Lower TRP and KYNA levels strongly correlate with symptom severity [43], while increased KYN/TRP ratios and reduced TRP characterize depressed adolescents at high suicide risk [44]
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