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Onset generally occurs in late adolescence or early adulthood
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cell proliferation and differentiation: MAPKK (MEK) 1/2 [S221/S225], ERK1 [T185/Y187], ERK2 [T185/Y187], ERK1/2 [T202/Y204]
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485 These findings indicate that mitochondria iron overload, combined with ROS formation and subsequent ferroptosis, intensifies the cardiotoxic effects of DOX-induced cardiomyopathy and may be an important mechanism
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