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This is because the manufacturer's stability data only guarantees the medication's potency and safety for 6 weeks once the seal has been broken
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However, proposed cartilage-, synovium-, subchondral bone-, or intra-articular anti-inflammatory effects remain largely hypothesis-generating in humans, with stronger support from preclinical, translational, or indirect mechanistic evidence than from KOA-specific clinical trials (Ryan et al., 2025)
According to the results, individuals prescribed semaglutide had a 40% to 70% lower risk for a first-time AD diagnosis within that 3-year window compared with the other medications
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