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On the other hand, a study with a different design, namely a randomized, double-blind, placebo-controlled crossover comparison clinical trial, and partially different cohort and methodologies demonstrated that daily oral administration of very low doses (1.5 g/day) of l-ARG for a very short time (17 days) did not improve patients satisfaction with their penile erectile function and their sexual life, analyzed by the standardized KEED questionnaire for ED, in 30 middle-aged men affected by ED of mixed etiology and severity [29], suggesting that higher doses and longer-term supplementation might be required, or that l-ARG might be of particular benefit in subtypes of ED, such as those of vasculogenic etiology

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however, some individuals may experience mild gastrointestinal discomfort or jitteriness due to caffeine