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A placebo-controlled, double-blind trial of DFO in early-stage PD showed reduced iron accumulation in the SN and delayed motor symptom progression (271)

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Conversely, other anti-amyloid mAbs (e.g., aducanumab) have demonstrated more favourable outcomes in recent trials, culminating in an FDA endorsement for treatment of early AD stages (dementia or mild cognitive impairment) ( 3.2.1 Parkinson's disease (PD) PD is a CNS movement disorder that primarily occurs in people over 60 years, with an estimated 1% prevalence in the population belonging to this age group