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Most research has focused on fat metabolism, while separate animal studies have also looked at joints and cartilage
Clues pointing to dehydration or dry eye: Burning, stinging, foreign body sensation Blurriness that improves with blinking Symptoms worse with screens, air conditioning, or at the end of the day Dark urine, orthostatic dizziness, headaches 3) Low Blood Pressure and Orthostatic Symptoms Can Mimic Vision Problems Weight loss, reduced intake, and improved metabolic health can reduce blood pressure
Target Population Obese adults without diabetes No prior diagnosis of obesity-associated cancers Mean age: 47.2 years (SD 14.8) Study period: December 2014 to June 2025 Study Design Design: Target trial emulation using retrospective cohort data Database: TriNetX nationwide database of 113 million US patients Total cohort: 229,467 patients Matched cohort: 161,798 patients after 1:1 propensity score matching 80,899 GLP-1RA users 80,899 diet/exercise counseling controls Validation: Inverse probability of treatment weighting analysis Endpoints Primary endpoint: Cumulative incidence of 13 obesity-associated cancers between treatment groups Secondary endpoints: Cancer incidence stratified by: Sex (female vs
Wilsons disease: a clinico-neuropathological autopsy study
