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Given the above and current knowledge, a clinically significant DDI between GLP1RAs and COCs is probably not expected, and there is no recommendation in any GLP1RA prescription sheet for dose adjustment of COCs in this context
VDAC is not only related to ATP synthesis but is also involved in Bax binding to mitochondria for mitochondrial-mediated apoptosis 32,33
If youre currently taking a GLP-1 medication (or are considering it) here are a few important tips: Talk to your doctor about any history of eye disease, especially diabetic retinopathy or glaucoma
Nature 353:668670 Agrawal S, Agrawal A, Said HM (2016) Biotin deficiency enhances the inflammatory response of human dendritic cells
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