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GABAergic Neurotransmission and Chloride Homeostasis GBM induces major perturbations to inhibitory GABAergic neurotransmission
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Then, either NADPH-dependent glutamate dehydrogenases (GDH) or other transaminases, including glutamate oxaloacetate transaminase 2 (GOT2) and glutamate pyruvate transaminase 2 (GPT2), convert glutamate into a-KG to meet the need for corresponding amino acids
FDA approved it in 2019 to increase pain-free light exposure in adults with erythropoietic protoporphyria
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