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This makes it a potential candidate for research into cognitive decline and brain health
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M.DonnanG
In settings of high leptin such as the chronic ICV leptin model, known mechanisms of glucose suppression centre on glutamatergic steroidogenic factor-1 (SF1) expressing, pro-opiomelanocortin (POMC), and agouti-related protein (AgRP) neurons in the ventromedial nucleus and arcuate nucleus of the hypothalamus, which primarily suppress hepatic glucose production and stimulate glucose uptake into BAT, muscle and the heart via peripheral neural and hormonal pathways 70
It can also be made in a lab into a dietary supplement, which is used widely in alternative medicine
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