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We sincerely thank all participants and their caregivers for their meaningful contributions. The class of drugs, derived from the protein in the venom of the Gila monster, a large black lizard with pink-orange markings, has sparked a revolution in the treatment of metabolic disease

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Mendelian randomization (MR) analyses allow for the use of single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) when assessing causal associations between a given exposure and a particular outcome, thereby helping to avoid the potential for confounding effects of reverse causality that can adversely affect conventional observational studies