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Intriguingly, recent investigations have demonstrated that irisin upregulates the expression of TFAM (mitochondrial transcription factor A) through the activation of the SIRT1/PGC-1 signaling pathway, thereby enhancing mitochondrial metabolism and mitigating microglial activation 18
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The expression of genes involved in (h)GSH biosynthesis, thiol content, and localization of the reduced form of GSH were analyzed in nodules of wild-type pea plants and mutants sym33-3 (weak allele, locked infection threads, occasional bacterial release, and defense reactions) and sym33-2 (strong allele, locked infection threads, defense reactions), and sym40-1 (abnormal bacteroids, oxidative stress, early senescence, and defense reactions)
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