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Discovery and Characterization Pickart and Thaler (1973) first isolated GHK from human plasma and characterized its copper-binding properties

Cardiolipin can be oxidized by ROS or by the cardiolipincytochrome c complex ( c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT

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