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Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

Remember, if something feels wrong, trust your instincts and stop using the product

Although the majority of deficiencies occur in developing countries such as in Africa (e.g., Cte dIvoire 14 ) and Asia (e.g., India 15 and Cambodia 13 ), also populations in developed countries can suffer from riboflavin deficiency due to inadequate intake via diet as a result of veganism 16,17 , lactose intolerance 18 , aging 19 , anorexia nervosa 20 , or alcoholism 21

Sergey Terushkin, MD, FACS