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Key Takeaways IGF-1 LR3 is an 83-amino-acid analog with roughly 1000-fold lower IGF-binding-protein affinity than native IGF-1, extending estimated half-life from minutes to approximately 20 to 30 hours in vitro

Back Brown, JC, Mutt, V, Pederson, RA (July 1970) 'Further purification of a polypeptide demonstrating enterogastrone activity', The Journal of Physiology , 209/1

Lorenzati B, Zucco C, Miglietta S, Lamberti F, Bruno G

In summary, the mechanistic picture suggests GLP-1 RAs could improve the fertile milieu by aiding weight loss and reducing metabolic inhibitors of fertility, and they may even directly improve certain sperm functions, but they are not magic bullets for restoring testosterone in severely obese or diabetic states (at least in isolation)