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Overexpression of Bcl-2, an anti-apoptotic protein, inhibits autophagy by binding to Beclin 1 and reducing PI3K activity [214, 215], underscoring the therapeutic potential of targeting this axis in cancer treatment
10.1016/S1002-0160(08)60039-9 149 YabutaY.MotokiT.YoshimuraK.TakedaT.IshikawaT.ShigeokaS
After removing duplicates entries and standardizing the data, 2,665 targets were obtained
Conversely, detached or metastatic tumor cells exhibit downregulated GLUT1 expression 43 , which impairs their glucose uptake and causes them to rely predominantly on lactate oxidation to fuel oxidative phosphorylation 40
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