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This new molecule, by acting synergistically on combined systems known to be altered in T2DM [33, 34], could indeed expand the therapeutic potential of GLP-1 agonists/analogues, suggesting new scenarios in terms of improving glycemic control, weight management, and hopefully providing protection against chronic micro-macrovascular complications and not only limited to hepatic complications
We approached this question using pharmacological models to induce a low or high TH state, followed by diurnal transcriptome analysis to evaluate a possible crosstalk between THs and the circadian clock
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Because of these influences throughout our history, many of our bodies and brains adapted to hold on to weight, to seek pleasurable foods and tend towards inactivity when ever we can (which is a lot these days!)
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