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The FDA label for semaglutide 2.4 mg mirrors these thresholds, which are consistent with the 2022 American Gastroenterological Association (AGA) guideline recommendations for pharmacotherapy in obesity [5]

History of Cancer or Family History of Colorectal Cancer: If you have a personal or family history of colorectal cancer, it is crucial to report any occurrence of blood in the stool to your doctor for further investigation