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However, when combined with GLP-1 activity to keep glucose in check, the glucagon component drives increased energy expenditure through thermogenesis, enhanced fat oxidation and breakdown, improved metabolic rate, and potential additional central appetite regulation through pathways that neither GLP-1 nor GIP can access alone

The results are the skins own collagen genuinely rebuilt, not filled or masked

The important caveat is scale

Exendin-4 increases mRNA expression of Il1b, Il6, Il22, Il12b, Tnfa, Ccl2, Cxcl1 , and Cxcl2 (innate immunity), regenerating islet-derived protein 2, RegIIIy and RegIIIB (anti-microbial proteins), as well as Il-5, Il-13 (pathogen clearance) within 4 h of administration, returning to baseline expression by 24 h (Yusta et al., 2015), suggesting that GLP-1R activation engages a cytoprotective response