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Although some authors have demonstrated an association between hyperhomocysteinaemia and free radical formation ( Reference Huang, Hsu and Lin 8 Reference Weiss 10 ) , the present study is the first to demonstrate that the reduction of plasma Hcy levels by creatine supplementation is associated with a significant reduction of plasma lipid peroxidation biomarkers (Table 3)

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Mayo Clin Proc 92:599604

concurrent tobacco smoking further augments thrombotic risk, and careful monitoring is advised when estrogens are co-administered with thyroid hormones, corticosteroids, or anticoagulants due to possible alterations in binding protein levels and pharmacodynamic response